Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. II. Isolation and physical-chemical characterization.
نویسندگان
چکیده
Glycothiohexide alpha was recovered from the fermentation broth of a "Sebekia" sp. by mixed solvent extraction, selective precipitation and adsorption chromatography on Diaion HP-20. The amount of glycothiohexide alpha present in the crude preparation was enriched by photolysis. Purification of glycothiohexide alpha was accomplished by repetitive countercurrent chromatography.
منابع مشابه
Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. III. Structural elucidation.
The chemical structure of a novel thiopeptide antibiotic, glycothiohexide alpha (1), isolated from the fermentation broth of a "Sebekia" species was determined based on extensive 2D NMR studies, as well as, IR, UV, and mass spectral data. The chemical structure of glycothiohexide alpha is closely related to nosiheptide (3) and antibiotic S-54832A.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 47 8 شماره
صفحات -
تاریخ انتشار 1994